Pharmaceutical drug improvement depends closely on the creation of amorphous strong dispersions (ASDs) to reinforce the dissolution fee and stability of energetic pharmaceutical components (APIs). Growing ASDs with the specified physico-chemical properties is a fancy and time-consuming course of that always entails the guide preparation of quite a few pattern compositions with various ratios of API and excipients.
This tedious and resource-intensive process has hindered the systematic exploration of formulation design house, leading to suboptimal formulations and slower drug improvement processes.
František Štěpánek’s group has addressed this problem by introducing the “spray drying robotic,” an modern machine that streamlines the preparation of ASDs. The spray drying robotic leverages a business laboratory spray dryer, enhancing it with three key parts: a computer-controlled feed mixing and pumping array, a cyclone cleaner to attenuate cross-contamination, and an autosampler for automated pattern assortment.
This mix permits researchers to supply powder samples with systematically various compositions throughout a single spray drying run, dramatically lowering the time and guide effort required for formulation improvement.
The importance of this breakthrough lies in its potential to speed up the pharmaceutical drug improvement course of. By automating the creation of multi-component powder samples, the spray drying robotic affords a sensible answer for large-scale screening research, permitting researchers to discover the formulation design house extra effectively and systematically. This time-saving innovation will considerably contribute to the event of superior and more practical drug merchandise.
Notably, this analysis marks a sensible restrict on the achievable “decision” within the composition design house. With the flexibility to pick from as much as 9 completely different feed options and assuming a conservative composition decision of 20 wt%, the spray drying robotic can generate as much as 1,287 distinct powder compositions, doubtlessly rising to 43,758 with a ten wt% decision. Whereas not all of those formulations could also be significant, the spray drying robotic empowers researchers to conduct formulation screening research with important time financial savings, minimizing the danger of lacking out on superior formulations.
František Štěpánek and his group on the College of Chemistry and Know-how Prague imagine that their innovation can have a transformative affect on the pharmaceutical business, providing researchers in each academia and business a extra environment friendly and efficient strategy to drug improvement. With this novel machine, they intention to drive the way forward for pharmaceutical formulation improvement and, finally, the creation of superior, life-changing medicine.
The work is revealed within the journal Powder Know-how.
Extra info:
Vojtěch Klimša et al, Spray drying robotic for high-throughput combinatorial fabrication of multicomponent strong dispersions, Powder Know-how (2023). DOI: 10.1016/j.powtec.2023.118872.
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Automating pharmaceutical spray drying for accelerated drug improvement (2023, October 31)
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