Brigham researchers have discovered that a reduction in the INPP5D gene in microglia leads to increased neuroinflammation, potentially contributing to the progression of Alzheimer’s disease, paving the way for targeted treatments.
A research study conducted by Brigham researchers has uncovered the way in which genetic alterations in specific brain cell types may play a role in the inflammation observed in Alzheimer’s disease.
Microglia, immune-regulating cells in the brain, are known to be involved in the development of DOI: 10.1038/s41467-023-42819-w
This work was supported by NIH grants P01AG015379, RF1NS117446, R01AG055909, U01AG072572 and U01AG061356.