Researchers at Penn State found that blocking an enzyme, histone deacetylase 3 (HDAC3), helps older mice incorporate new information into existing memories, performing as well as younger mice. This discovery could lead to treatments that improve memory updating in the elderly and potentially aid in combating Alzheimer’s disease and other dementias.
Penn State researchers discovered that blocking the enzyme HDAC3 improves memory updating in older mice, potentially offering new treatment avenues for age-related cognitive decline and memory disorders such as DOI: 10.3389/fnmol.2024.1429880
Other Penn State authors on the paper include Lauren Bellfy, doctoral student in the molecular, cellular and integrative biosciences, and Chad Brunswick, a doctoral student in the neuroscience program. Destiny Wright and Sofia Bennetts, who were undergraduate students at Penn State during the time of the research; Mark Urban, a postdoctoral scholar at Penn State during the time of the research; and Guanhua Shu, who was a graduate student at Harvard University at the time of the research, also contributed to the paper.
Funding from the National Institute on Aging, Hevolution/American Federation for Aging Research, and the Penn State Paul Berg Early Career Professorship funded this research.
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