A recent study has identified new compounds that can significantly enhance the effectiveness of naloxone, a lifesaving drug used to reverse opioid overdoses. These compounds help naloxone work longer and more powerfully, offering hope in the fight against the escalating opioid epidemic.
Newly identified compound enhances naloxone’s potency and duration, according to a mouse study.
The ongoing opioid crisis in the U.S. claims tens of thousands of lives annually. Naloxone, known by its brand name Narcan, has been instrumental in saving numerous lives by reversing opioid overdoses. However, the emergence of new, more potent opioids is making it increasingly challenging for first responders to revive individuals who overdose.
Now, researchers have found an approach that could extend naloxone’s lifesaving power, even in the face of ever-more-dangerous opioids. A team of researchers from Washington University School of Medicine in St. Louis, Stanford University and the DOI: 10.1038/s41586-024-07587-7
The study was funded by the American Diabetes Association, the American Heart Association, the
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