Cardinals vs. Reds odds, line, prediction: 2022 MLB picks, Friday, April 22 best bets from top computer model

Cincinnati will be hoping to snap its nine-game losing streak when it opens a three-game series against National League Central rival St. Louis on Friday night. The Reds opened the year with a four-game split against reigning World Series champion Atlanta, but they have not won a game since then. St. Louis is looking to bounce back from a disappointing 5-0 loss at Miami.

First pitch is set for 6:40 p.m. ET from Great American Ball Park in Cincinnati. St. Louis is listed as a -125 favorite (risk $125 to win $100) in the latest Cardinals vs. Reds odds from Caesars Sportsbook, with the over-under set at 7.5 runs. Before making any Reds vs. Cardinals picks, you need to check out the latest MLB predictions and betting advice from the SportsLine Projection Model.

The model, which simulates every MLB game 10,000 times, is off to a sizzling start to the 2022 season. It’s on a 14-4 roll on top-rated MLB money-line picks through two weeks, returning over $800 for $100 players. Anyone following it has seen huge returns.

Now, the model has locked in on Reds vs. Cardinals, and just locked in its picks and MLB predictions. You can visit SportsLine now to see the model’s picks. Here are the MLB odds and trends for Cardinals vs. Reds:

• Cardinals vs. Reds money line: St. Louis -125, Cincinnati +105
• Cardinals vs. Reds run-line:  St. Louis -1.5 (+140)
• Cardinals vs. Reds over-under: 7.5 runs 
• STL: The Cardinals are 7-4 ATS this season
• CIN: The Reds are 4-9 ATS this season

Featured Game | Cincinnati Reds vs. St. Louis Cardinals

Why you should back the Reds

Cincinnati has its most promising starting pitcher on the mound for Friday night’s game. Hunter Greene has been consistently hitting 100 mph on the radar gun. He has also struck out 13 batters and walked just two through his first two MLB starts, so his control has been excellent. 

Greene is facing a St. Louis lineup that tends to go cold at times, as evidenced by its 5-0 loss to Miami on Thursday. Meanwhile, St. Louis starter Steven Matz has already allowed seven runs through his first 8.2 innings this season, so he has not been sharp. Cincinnati has value as a home underdog, especially due to its motivation to snap the losing skid. 

Why you should back the Cardinals

Cincinnati is not only in the midst of a nine-game losing streak, but it is also dealing with several key injuries. The Reds will be without star second baseman Jonathan India, catcher Tyler Stephenson and third baseman Mike Moustakas, among others. They rank outside the top 25 in runs (2.85) and batting average (.177) this season.

St. Louis third baseman Nolan Arenado is off to an outstanding start, hitting .405 with five home runs. The Cardinals are inside the top 10 in runs (4.55) and home runs (13) this season, giving them an edge over a lifeless Cincinnati lineup. Greene has relied on strikeouts through his first two starts, but St. Louis has struck out the second-fewest number of times (81) this year. The Reds are 7-20 in their last 27 games as home underdogs, while St. Louis is 11-3 in its last 14 road games against a right-handed starter. 

How to make Cardinals vs. Reds picks

SportsLine’s model is leaning over on the total, projecting 9.3 combined runs, and it also says one side of the money line has all the value. You can only get the model’s pick at SportsLine. 

So who wins Reds vs. Cardinals? And which side of the money line has all the value? Visit SportsLine now to see which side to jump on, all from the advanced model that has crushed its top-rated MLB picks, and find out.