A study by the MRC Laboratory of Medical Sciences reveals that cells in different organs selectively express maternal or paternal X chromosomes. This variation, shown in both human data and mouse models, is driven by cellular competition, affecting organ development in biological females. Credit: SciTechDaily.com
Research reveals that selective expression of maternal or paternal X chromosomes varies by organ, driven by cellular competition.
A new study published today (July 26) in Nature Genetics by the Lymphoid Development Group at the MRC Laboratory of Medical Sciences has revealed that the contribution of cells expressing maternal or paternal X chromosomes can be selectively skewed in different parts of the body. The study leverages human data from the 1000 Genomes Project combined with mouse models of human X chromosome-linked
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