Malaria-Free Game Reserves ~ For those seeking an unforgettable Big 5 wildlife experience without the worry of malaria, South Africa offers an array of top-notch, malaria-free game reserves. These lodges provide a 4 to 5-star safari experience, allowing you to witness Africa’s most iconic wildlife in their natural habitat—safely and comfortably.
If you’re looking for the ultimate luxury safari, don’t miss our Exclusive Use Safari Villas article, which highlights private escapes perfect for those seeking an even more intimate adventure. And if you’re traveling with young ones, be sure to check out our Kids at Game Lodges article, as many reserves are incredibly family-friendly.
In the heart of South Africa’s North West Province, the Pilanesberg and Madikwe Game Reserves offer Big 5 game viewing on par with the best Africa has to offer. Similarly, the Waterberg region in Limpopo—home to Welgevonden Game Reserve—boasts some of the country’s most exquisite wildlife experiences, with a focus on conservation and luxury.
One of the greatest advantages of these reserves is that you can enjoy the thrill of the Big 5 without the hassle of taking anti-malaria medication. While the Kruger National Park is often at the top of many first-time safari-goers’ lists, it’s important to note that it’s located in a moderate-risk malaria zone. This means you’ll need to take anti-malarial pills between September and May.
Thankfully, malaria-free game reserves are abundant across South Africa, including the Eastern Cape, North West, Madikwe, Waterberg, and Northern Cape. These regions offer a safe and enjoyable safari experience where your focus can remain solely on the breathtaking wildlife surrounding you.
Explore our carefully curated list of top malaria-free Big 5 game reserves to plan your dream safari experience.
Malaria-free game reserves in the Garden Route
Gondwana Game Reserve
Just 4 hours from Cape Town, Gondwana offers an unparalleled Garden Route safari experience, blending luxury with the thrill of the Big 5. Spanning over 11,000 hectares, this private, malaria-free reserve promises an immersive, free-roaming wildlife encounter in an awe-inspiring landscape.
Guests can choose from romantic, standalone safari suites, perfect for couples, or spacious bush villas designed for families and groups, all with breathtaking mountain views. Enjoy gourmet dining, exhilarating game drives led by expert guides, and the renowned Junior Ranger Program for younger guests.
The Spa invites relaxation with treatments amid nature’s beauty. Nearby, world-class golf courses, coastal towns, and adventure activities add even more appeal to this luxurious retreat in the Southern Cape.
Garden Route Game Lodge
The popular Garden Route game lodge is situated at the gateway to the Garden Route Coast, where it stands proudly against the stunning backdrop of the Langeberg Mountain Range. Just a 3.5-hour drive from Cape Town, this private, malaria-free reserve offers a sanctuary for diverse wildlife, including the iconic Big Five.
Guests are invited to embark on open-air Land Rover safaris, savor luxury accommodations, and experience unforgettable dining in the Boma restaurant. With attentive service from our welcoming staff, every detail of your stay is thoughtfully curated to create lasting memories.
Botlierskop Private Game Reserve
Discover the magic of Botlierskop Private Game Reserve, where over 26 animal species roam free across 4,200 hectares under the watchful gaze of the Outeniqua Mountains. From thrilling game drives to horseback safaris, explore this stunning landscape and encounter rhinos, lions, giraffes, and the rare black impala.
Retreat to your luxurious tented suite, complete with a four-poster bed, bush-view shower, and colonial charm. Whether you’re looking to unwind at the bush spa or share a family adventure, Botlierskop promises an unforgettable escape in the heart of the Garden Route!
Malaria-free wildlife reserves in the Eastern Cape
Samara Karoo Reserve
Discover the magic of Samara Private Game Reserve in the heart of the Eastern Cape! Overnight in luxurious comfort and then embark on thrilling walking safaris, and experience unforgettable moments like a night under the stars in the romantic star bed.
Explore 70,000 acres of pristine wilderness, meet the endangered cheetah, and dive into a world of history, wildlife, and adventure. Perfect for families, couples, and nature lovers.
Gorah Elephant Camp
Step into the timeless allure of Gorah Safari Lodge, where the thrill of watching elephants wander past the verandah is just another day in the African bush. Nestled in Addo Elephant Park, this 5-star retreat blends colonial charm with the wild elegance of Africa, offering you an unforgettable taste of safari life.
Indulge in luxury tented suites, savor gourmet meals overlooking the waterhole, and venture on game drives to spot the Big Five. Gorah is more than a stay; it’s an enchanting journey back to the golden age of safari. Are you ready for the adventure?
Ukhozi Lodge at Kariega
Escape to the heart of Kariega’s wilderness at Ukhozi Lodge, where African romance meets luxury. Each private log suite features a plunge pool and deck with sweeping valley views, perfect for unwinding after thrilling safari drives, river cruises, and bush walks.
Relax in African-style lounges, dine on exquisite cuisine, and soak in the magic of the bush. Ukhozi Lodge offers an unforgettable escape.
Amakhala Safari Lodge
Escape to Safari Lodge, tucked away in the heart of the Amakhala Game Reserve, where nature and luxury meet. Enjoy stunning Big 5 game drives, river cruises, and guided walks in this Malaria-free game reserve.
Relax in beautifully designed safari huts with all the comforts of a five-star lodge, including private pools, outdoor showers, and spectacular views. Indulge in all-inclusive meals and unforgettable experiences in this intimate, wildlife-rich retreat.
Shamwari Long Lee Manor
Discover the heart of Shamwari Long Lee Manor, nestled along the Bushmans River between Port Elizabeth and Grahamstown. Immerse yourself in an unforgettable African adventure where conservation meets luxury, and explore the Big 5 in five unique ecosystems.
Stay in elegant, Edwardian-style suites overlooking expansive plains teeming with wildlife. Enjoy guided game drives, breathtaking views, and authentic, responsible tourism experiences that bring you closer to nature while embracing the area’s rich heritage.
Hillsnek Safaris
Discover HillsNek Safaris, an exclusive-use lodge set along the Bushman’s River in the breathtaking Amakhala Game Reserve. Enjoy panoramic views from your private luxury tent and craft your own adventure with a dedicated host, chef, and ranger. This malaria-free sanctuary in the Eastern Cape offers guided game drives, gourmet meals, and unmatched privacy.
Immerse yourself in the magic of the African wilderness, with Big 5 encounters, abundant wildlife, and unique conservation efforts. End your day by the solar-heated pool or under the stars, surrounded by the timeless beauty of the African bush.
Kwandwe Great Fish River Lodge
Set against the dramatic Eastern Cape landscape, Great Fish River Lodge at Kwandwe Private Game Reserve offers a luxurious safari escape along the Garden Route. This exclusive, malaria-free reserve spans 22,000 hectares and provides incredible Big 5 encounters, while also protecting rare species like the blue crane, black rhino, and cheetah. Each suite offers en-suite bathrooms, outdoor showers, and private plunge pools with sweeping views.
Start your days with thrilling game drives and end them with gourmet dinners under the stars. Family-friendly adventures await too—from treasure hunts and fishing trips for kids to eco-education and community visits. Dive into a safari experience that blends conservation with luxury and memorable moments for all.
Sibuya Game Reserve
Discover the wild beauty of Sibuya Game Reserve, where luxury meets untamed nature on the Sunshine Coast. Nestled along the Kariega River, this malaria-free haven offers unforgettable Big 5 safaris, scenic river cruises, and pristine beaches just a short boat ride away. With nearly 400 bird species and diverse wildlife, Sibuya provides one of South Africa’s most vibrant game-viewing experiences.
Stay in luxury tents at secluded river or forest camps, where you can tailor your adventure with thrilling game drives, guided walks, or serene afternoons by the water. Unplug, unwind, and let breathtaking landscapes and tranquil campfire evenings captivate you.
Woodbury Lodge
Experience the magic of Woodbury Lodge, perched above the Bushman’s River Valley in the malaria-free Amakhala Game Reserve. With incredible views and thrilling Big 5 sightings, this secluded retreat offers the perfect escape in the Eastern Cape.
Stay in luxurious stone-and-thatch lodges with private viewing decks, enjoy delicious meals with a view, and immerse yourself in daily game drives and river cruises. Discover a reserve committed to conservation and reconnect with nature in a truly unforgettable way.
Malaria-free reserves in the Western Cape
Sanbona Wildlife Reserve
Discover the wild beauty of Sanbona, a 58,000-hectare sanctuary nestled between the Warmwaterberg Mountains. Just three hours from Cape Town, this is the Western Cape’s premier Big 5 wildlife destination where vast plains, ancient rock art, and star-studded skies await.
Choose from luxurious lodges or a back-to-nature Explorer Camp, and embark on unforgettable game drives, nature walks, and stargazing adventures. Experience the Little Karoo’s raw magic at Sanbona—a place where nature and history intertwine.
White Lion Lodge at Sanbona
Nestled within the Sanbona Wildlife Reserve, the White Lion Lodge offers a luxurious yet unpretentious retreat for up to eight guests. Four private suites each feature panoramic views from the private verandas, allowing guests to immerse in the natural beauty of the surrounding riverbed and Karoo landscape.
Guests can unwind by the 15-meter rim-flow pool, reserve a wood-fired hot tub, or enjoy an evening drink by the lodge’s crackling fireplace. South African cuisine is served in the dining room or under the open sky.
A private game vehicle and expert guide allow for exclusive wildlife excursions, including bush walks to explore the 54,000-hectare reserve’s mountains, plains, and rock art.
Aquila Private Game Reserve
Just a short drive from Cape Town, Aquila Private Game Reserve offers an unforgettable Big 5 safari experience set amidst the breathtaking Karoo landscapes. Explore this malaria-free, 4,500-hectare sanctuary rich in Khoi San and Boer War history, with stunning mountains, valleys, and rivers.
Beyond the safari, Aquila’s restaurant, pool bar, and cigar bar invite you to unwind in true style. Kids can join the Junior Rangers program for hands-on conservation activities, while guests of all ages can enjoy traditional vehicle safaris led by expert guides. From spotting majestic wildlife to relaxing in nature, Aquila is a Cape Town must-see!
Inverdoorn Game Reserve
Just a two-hour drive from Cape Town, Inverdoorn Private Game Reserve offers a true safari escape with over 1,200 animals, including the Big Five, roaming free across 10,000 hectares. This malaria-free reserve is also home to the renowned Western Cape Cheetah Conservation, where you can witness thrilling cheetah runs or even meet tame cheetahs up close—a perfect, memorable addition to any Cape Town itinerary.
Choose from luxurious accommodations, unwind by the pool, or indulge in a relaxing in-room spa treatment. With immersive 4×4 game drives, stargazing, and a lush cactus garden, Inverdoorn invites you to experience the breathtaking beauty of the Karoo while connecting with South Africa’s incredible wildlife.
Malaria-free reserves in the North West Province
Mbazo Safari Lodge in Pilanesberg
Escape to Mbazo Lodge, a luxurious safari retreat nestled within the Black Rhino Game Reserve, part of the malaria-free Pilanesberg National Park. With exclusive access to the Big 5, rare antelope, and over 350 bird species, your adventure includes two daily guided game drives and all-inclusive meals, ensuring an unforgettable wildlife experience.
Relax in one of five elegant en-suite rooms, each complete with air conditioning, private patios, and satellite TV. Between game drives, unwind by the pool, enjoy a cozy guest lounge, or explore unique activities like hot air ballooning and cultural museum tours.
Shepherds Tree Game Lodge
Discover the luxurious Shepherd’s Tree Game Lodge, a five-star haven set within the malaria-free Pilanesberg Game Reserve. Located just two hours from Johannesburg, this exclusive lodge offers private access to an untouched wilderness zone, promising close encounters with the Big 5 and breathtaking views of the vast bushveld.
Indulge in upscale suites with commanding vistas, relax by the rim-flow pool, and savor gourmet cuisine in the boma or wine cellar. With a spa, dedicated game drives, and a serene, secluded setting, Shepherd’s Tree Game Lodge invites you to experience the true essence of African safari luxury.
Lush Private Lodge
Experience ultimate luxury in the heart of the Pilanesberg at Lush Private Lodge, nestled in the Black Rhino Game Reserve. With only 8 exclusive suites, each with private decks, splash pools, and stunning mountain or bush views, this intimate lodge offers an unforgettable Big 5 safari experience.
Guests enjoy all-inclusive dining, personalized service, and thrilling game drives through this malaria-free sanctuary. Savor every moment with gourmet meals, a serene spa, and a lively waterhole teeming with wildlife, visible from the lodge’s expansive viewing decks.
The Last Word Madikwe
Step into the warmth of the house, where a former farmhouse in the Madikwe Game Reserve has been transformed into an intimate safari retreat. With only six en-suite rooms and a personal, owner-managed touch, this is more than just a lodge—it’s a welcoming home where every guest feels like family.
Experience true relaxation as you watch wildlife roam at the waterhole just meters from the lush garden. Enjoy all-inclusive dining, twice-daily Big 5 game drives, and serene moments in the garden or by the pool.
Motswiri Private Safari Lodge
Experience a truly personal safari at Motswiri Private Safari Lodge in Madikwe, where luxury villas open to breathtaking views and wildlife sightings from private decks. Relax in style with double-sided fireplaces, outdoor showers, and the lodge’s stunning rim-flow pool overlooking a bustling waterhole.
With all-inclusive dining under the stars, twice-daily Big 5 game drives, and serene outdoor lounges, Motswiri offers an unforgettable blend of adventure and tranquility.
Tau Game Lodge
Tau Game Lodge in Madikwe Game Reserve is where Big 5 sightings and unforgettable wildlife encounters await at the waterhole. With 30 thatched chalets featuring private decks, open-air showers, and spacious family options, Tau offers the perfect mix of adventure and relaxation.
Savor meals under the stars in cozy bomas, unwind by the infinity pool, and let kids enjoy the exciting Tau Cubz Club with game drives and wildlife activities designed just for them.
Tambuti Lodge
Escape to Tambuti Lodge in Black Rhino Game Reserve, where luxury meets the wild. Just 33km from Sun City, this intimate lodge offers unforgettable game drives and walks, with Big 5 sightings and endless birdwatching moments right at your doorstep.
Stay in one of five stylish suites, each with a private patio, indoor and outdoor showers, and all the comforts of home. Enjoy gourmet meals, sundowners in the boma, and refreshing dips in the rim-flow pool for a perfect bush retreat.
Ivory Tree Game Lodge
Discover Ivory Tree Game Lodge in Pilanesberg National Park, where luxury meets the wild. Enjoy all-inclusive meals, game drives, and stunning views from your room or the feature pool overlooking the new waterhole.
Relax in spacious accommodations, from standard rooms to the private Executive Suite with its own plunge pool. With a world-class Amani Spa, thrilling activities like quad biking and archery, and unforgettable Big 5 safaris, Ivory Tree is your perfect bush escape.
Thakadu River Camp
Experience the beauty of Madikwe Game Reserve, a malaria-free haven where diverse ecosystems meet. Thakadu River Camp offers 12 luxurious tented suites, each with a private deck overlooking the Marico Rive.
Immerse yourself in the unique Afro-Asian inspired design, relax by the pool, and enjoy world-class hospitality in the heart of nature. With all meals included, guided game drives, and the stunning river setting, Thakadu is the ultimate bush getaway.
Rockfig Lodge Madikwe
Escape to Rockfig Lodge in the malaria-free Madikwe Game Reserve for an unforgettable safari experience. Offering self-catering luxury villas and suites, you’ll enjoy breathtaking views, private pools, and a unique underground hide for up-close wildlife viewing.
With the chance to spot the ‘Magnificent 7’ and beyond, your stay combines comfort with adventure. Whether it’s a family villa, intimate suite, or a wildlife encounter like no other, Rockfig Lodge immerses you in the beauty of the African bush.
Etali Safari Lodge
At Etali Safari Lodge in the heart of Madikwe Game Reserve, luxury meets nature. With private heated whirlpools, breathtaking views, and indulgent massages on your sundeck, every moment here rejuvenates body and soul.
Enjoy all meals, guided game drives, and the thrill of spotting the Big 5 in a malaria-free zone. Dining at Etali is a fusion of African and Asian flavors, while the unique wine cellar and open-air boma offer the perfect setting to unwind after a day of safari adventures.
Royal Madikwe Luxury Safari Lodge
Nestled in the heart of Madikwe Game Reserve, this exclusive retreat offers breathtaking views, private pools, and unforgettable Big 5 encounters. Enjoy guided game drives, bush walks, and top-tier dining—all set in a malaria-free paradise.
Relax in your suite with premium amenities, indulge in spa treatments, or join in exciting activities like cultural drumming and archery.
Malaria-free wildlife Big-5 reserves in Limpopo
Mabula Game Lodge
Set in the malaria-free Waterberg region, Mabula offers an unforgettable Big 5 adventure, surrounded by stunning landscapes and abundant wildlife. Relax in comfortable thatched accommodations with panoramic views, and indulge in mouthwatering cuisine, from impala casseroles to traditional South African dishes under the stars.
Mabula isn’t just about game drives – it’s about experiences. Enjoy quad biking, horseback safaris, stargazing, and a kid-friendly program for young explorers.
Zwahili Private Game Lodge
Escape to Zwahili Game Lodge, just 2 hours from Johannesburg, where breathtaking sunsets and tranquil evenings await. Enjoy guided game drives, serene bush walks, and cozy evenings by the fire, all set in a malaria-free paradise.
Unwind in luxurious rooms and suites, each with stunning views and top-tier amenities. With exceptional wildlife sightings, over 400 bird species, and a rich history to explore, Zwahili Game Lodge offers an unforgettable experience for adventure and relaxation.
Wild & Free Game Lodge
Escape to Wild & Free Game Lodge, nestled in the malaria-free Waterberg Mountains, just two hours from Johannesburg. With the Big 5, hippos, giraffes, and over 250 bird species, experience the ultimate bushveld getaway on a private 12,000-hectare reserve.
Stay in luxurious executive chalets with stunning views, outdoor showers, and cozy fireplaces. Enjoy all-inclusive meals, guided game drives, and unforgettable adventures like walking with rhinos or visiting cheetahs.
Bushwa Private Game Lodge
Bushwa Game Lodge is a hidden gem in the Waterberg biosphere, just 250 km from Johannesburg. Choose from luxury safari tents or a romantic treehouse, and immerse yourself in the bush, where the Big 5 roam and night animals like hyena and jackal make their appearance.
Indulge in all-inclusive meals, guided game drives, and thrilling activities like rhino tracking and horseback safaris. Unwind at the Tsamma Bush Spa, or enjoy a traditional bush braai under the stars—Bushwa offers a wild escape that will captivate your heart.
Mhondoro Safari Lodge
Escape to the heart of the malaria-free Welgevonden Game Reserve, where luxury meets tranquility at Mhondoro Game Lodge. Just 2.5 hours from Johannesburg, this exclusive retreat offers breathtaking views, intimate wildlife sightings, and five-star accommodation for a maximum of 10 guests.
Indulge in gourmet dining, relax by the waterhole, and embark on thrilling Big 5 game drives. Unwind in the spa, enjoy a refreshing swim, or simply soak in the serene surroundings—Mhondoro offers an unforgettable safari experience.
Tintswalo Waterberg
Discover Tintswalo Waterberg, a luxury escape in the malaria-free Welgevonden Game Reserve, home to the Big 5 and breathtaking views. With three elegant suites, gourmet meals, and daily game drives, it’s the perfect place to reconnect with nature.
Enjoy unforgettable moments, from starlit Boma dinners to wildlife sightings from the lodge’s viewing deck. Relax by the pool, indulge in luxury, and experience the ultimate safari retreat.
Safari Plains Lodge
Escape to Safari Plains, where luxury meets the wild in the heart of the Waterberg. Just a short drive from Johannesburg, this malaria-free paradise offers Big 5 game drives, guided bush walks, and elegant tented suites with private decks and stunning views.
Whether on a morning safari or indulging in unique activities like hot air balloon rides and family-friendly adventures, Safari Plains guarantees an unforgettable getaway.
Nedile Lodge
Discover Nedile Lodge, nestled in the malaria-free Welgevonden Game Reserve, home to the Big 5 and one of the largest private white rhino collections. Experience luxurious accommodation in five exclusive suites, each with stunning views of the Waterberg mountains, indoor and outdoor showers, and all the comforts of home.
Indulge in five-star dining, unwind by the rock pool, or embark on thrilling game drives and bush walks with expert rangers.
Ndlovu Safari Lodge
Experience the luxury of Ndlovu Safari Lodge in the heart of the malaria-free Welgevonden Game Reserve. Set amidst breathtaking river ravines and mountains, this exclusive sanctuary offers elegant suites with private plunge pools, outdoor showers, and all-inclusive dining.
Immerse yourself in Africa’s Big 5 on guided game drives or bush walks, and unwind in the lodge’s spa, bar, or restaurant.
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