A study by UCSF researchers has found that the increase in smoking fentanyl, now more common than injecting, carries heightened overdose risks due to residue left in smoking equipment. Credit: SciTechDaily.com
As smoking
The paper, published today (May 22, 2024) in the scientific journal PLOS ONE, is the first to explore fentanyl resin as a key contributor to overdose.
Smoking fentanyl is rising locally and nationally
San Francisco reached an all-time of 806 deaths in 2023, with 653 from fentanyl. Nationwide, the number of fentanyl deaths declined modestly in 2023, dropping from 76,226 to 74,702; but they remain high, and fatal overdoses from psychostimulants, including methamphetamine and cocaine, are on the rise.
In recent years, mirroring national trends, fewer people in San Francisco have been injecting fentanyl and more have been smoking it. However, the beliefs and behaviors surrounding this development have not been well understood to date.
To conduct the study, the researchers observed people in their own environment in 2022, conducting face-to-face interviews with 34 participants who were recruited from syringe service programs. They asked about the progression of the participants’ substance use, as well as their modes of use, experiences with overdose, and the changes they had observed in the local drug supply. The interviews were supplemented with daily field notes, video-recorded smoking sequences, and photography of drugs and equipment.
The researchers observed that fentanyl was extremely cheap, as low as $10 a gram; and most people used foil to smoke it, although glass bubbles, bongs, and dabbing devices also were popular. The quality of the fentanyl varied, and people had no apparent method to determine it. Participants could gauge potency upon inhalation, however, and they had developed techniques to regulate their dose. Several participants reported frequent use, up to one or more grams a day.
Shared equipment poses significant dangers
It was both the difficulty of injecting and the fear of overdose that motivated people to start smoking fentanyl instead. Smoking was also more social, and people shared equipment, drugs, and information. The researchers were surprised to find that this caused participants to reflect on the changing risk environment for people with varying opioid tolerances and to develop strategies to protect others.
Early during fieldwork, the researchers observed an interaction in which a random person attempted to borrow a glass pipe from a participant, who vehemently refused. The participant explained that the pipe had been used for fentanyl and did not want to share it with someone who only used methamphetamine. Smoked fentanyl and methamphetamine residues look similar, and the equipment used often overlaps.
“The overdose risk arises when there is a potential mismatch between the potency of the residual drug and the recipient’s tolerance,” Ciccarone explained.
While some participants took precautions to prevent others from using their smoking equipment and overdosing on the residues, the shared smoking culture still poses increased risks, particularly given high consumption rates.
“This highlights the need for data that can inform harm reduction education that is understanding of and responsive to the perceptions of people who use opioids,” Ciccarone said. “Pacing, increasing awareness of dosages consumed, and checking tolerance of residue recipients are potentially viable interventions deserving further exploration.”
Reference: “Innovation and adaptation: The rise of a fentanyl smoking culture in San Francisco” 22 May 2024, PLOS ONE.
DOI: 10.1371/journal.pone.0303403