CyanVac LLC is set to begin a federally funded Phase 2b trial this fall for its intranasal COVID-19 vaccine, CVXGA, comparing it to an mRNA vaccine in 10,000 participants. Developed at the University of Georgia, the vaccine utilizes a unique delivery platform and aims for enhanced long-term protection against the virus.
The trial will evaluate the effectiveness and safety of a new vaccine compared to an FDA-approved mRNA vaccine.
University of Georgia-based startup CyanVac LLC has received federal funding to conduct a Phase 2b clinical trial to compare its intranasal vaccine candidates, CVXGA, which are designed to provide protection against 
Biao He in his laboratory. Credit: Andrew Davis Tuckert
“We are very excited about this opportunity to test a novel intranasal COVID vaccine whose technology platform has been developed at UGA,” said He, who is based in UGA’s Department of Infectious Diseases. “The name of our vaccine—CVXGA—is a tribute to UGA and CVM whose support over the years made this possible.”
Project NextGen’s goal is to advance new, innovative vaccines and therapeutics that provide longer lasting and more durable protection against COVID-19. The award is one of the first made through the Rapid Response Partnership Vehicle, a consortium funded by the HHS Biomedical Advanced Research and Development Authority (BARDA) to accelerate product and technology development.
The Phase 2b study, which will begin this fall, will be carried out by BARDA’s Clinical Studies Network, focusing on evaluating the vaccine in a subset of participants who are at a higher risk of severe disease.
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