New research has uncovered significant age-related changes in lipid metabolism across different organs and sexes in mice, highlighting the accumulation of specific lipids produced by gut bacteria. The findings, which also include the identification of a gene causing sex differences in the kidneys, could improve our understanding of age-related diseases like Alzheimer’s and atherosclerosis. This research provides a foundation for future studies on the human lipidome and microbiome, potentially leading to targeted treatments for these conditions. Credit: RIKEN
RIKEN Center researchers have found key age-related changes in mice’s lipid metabolism, potentially improving treatments for age-related diseases.
Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have identified multiple age-related alterations in lipid metabolism in mice, affecting various organs and differing by sex. Notably, they observed a systemic accumulation of specific lipids originating from gut bacteria as the mice aged. Additionally, the study revealed a sex-related difference in the kidneys and identified a gene linked to this variation. Published in Nature Aging, these findings could enhance our understanding of chronic age-related diseases such as DOI: 10.1038/s43587-024-00610-6