A new study reveals that psilocybin, found in “magic mushrooms,” induces a dynamic state of brain hyperconnectivity associated with the sensation of oceanic boundlessness and ego-altering experiences. These findings could improve the therapeutic use of psychedelics in treating mental health disorders such as depression. Credit: SciTechDaily
Study shows 
A new study finds a pattern of psilocybin-induced dynamic hyperconnectivity in the brain, which is linked to oceanic boundlessness. Credit: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Psilocybin generates profound alterations both at the brain and the experiential level. The brain’s tendency to enter a hyperconnected-hyperarousal pattern under psilocybin represents the potential to entertain variant mental perspectives. The findings of the new study illuminate the intricate interplay between brain dynamics and subjective experience under psilocybin, providing insights into the neurophysiology and neuro-experiential qualities of the psychedelic state.
Ramaekers adds, “Taken together, averaged and dynamic connectivity analyses suggest that psilocybin alters brain function such that the overall neurobiological pattern becomes functionally more connected, more fluid, and less modular.”
Insights From fMRI Studies
Previously acquired functional magnetic resonance imaging (DOI: 10.1016/j.bpsc.2024.04.001