Two recent studies by Columbia University scientists reveal a significant error in stem cell research: the gut’s stem cells identified over 15 years ago are not the actual stem cells. New tools have uncovered the true stem cells, which are located differently and could reshape the field of regenerative medicine by enabling therapies that repair various organs.
DOI: 10.1016/j.cell.2024.05.001
“Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury” by Ermanno Malagola, Alessandro Vasciaveo, Yosuke Ochiai, Woosook Kim, Biyun Zheng, Luca Zanella, Alexander L.E. Wang, Moritz Middelhoff, Henrik Nienhüser, Lu Deng, Feijing Wu, Quin T. Waterbury, Bryana Belin, Jonathan LaBella, Leah B. Zamechek, Melissa H. Wong, Linheng Li, Chandan Guha, Chia-Wei Cheng, Kelley S. Yan, Andrea Califano and Timothy C. Wang, , Cell.
DOI: 10.1016/j.cell.2024.05.004
Andrea Califano is founder, equity holder, and consultant of DarwinHealth Inc., a company that has licensed from Columbia University some of the algorithms used in this manuscript. Columbia University is also an equity holder in DarwinHealth Inc. U.S. patent number 10,790,040 has been awarded related to this work, assigned to Columbia University with Andrea Califano as an inventor.
The research was funded by the
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