The fate of a mutating virus provides crucial insights for preparing for pandemics.
Over the past century, a previously lethal mosquito-borne DOI: 10.1038/s41586-024-07740-2
This work was supported by Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease Awards, Vallee Scholar Award), Smith Family Foundation Odyssey Award, Charles E.W. Grinnell Trust Award, NIH grant R01 AI182377, a G. Harold and Leila Y. Mathers Foundation Award, NIH grant T32AI700245, T32GM144273, NIH grant R24 AI120942, Jackson-Wijaya Fund, NIH T32 CA009216-40, and NIH grant R01 MH125162.
The authors acknowledge the Micron (Microscopy Resources on the North Quad) Core, the Molecular Electron Microscopy Core Facility, and the Immunology Flow Cytometry Facility at Harvard Medical School for their support and assistance. The authors acknowledge Grace H. Raphael at the University of Texas Medical Branch for contributing to experiments involving authentic viruses.