Recent research shows cocoa extract supplements may benefit cognition in older adults with poor diets, but not in those with healthy diets, according to a study within the larger COSMOS trial.
Cocoa extract has shown a potential protective effect on cognition but randomized clinical trials in older adults have had inconsistent results. A new study of cognition in a randomized trial, known as the Cocoa Supplement and Multivitamin Outcomes Study (COSMOS), suggests that taking cocoa extract supplements containing 500 mg per day of cocoa flavanols had cognitive benefits for older adults who had lower habitual diet quality at the time of enrollment in the study. However, cognitive benefits were not found among participants who already had healthy dietary patterns at the start of the study.
The study, conducted by researchers at Mass General Brigham, included 573 older adults who underwent detailed, in-person cognitive testing and was published on December 7 in The earlier study that used a web-based cognitive assessment given over the internet to a separately recruited set of COSMOS participants.
COSMOS Trial and Broader Implications
COSMOS is an investigator-initiated large-scale, long-term clinical trial led by Brigham and Women’s Hospital. More than 21,000 older women and men were enrolled across the United States to participate in this randomized, double-blinded, placebo-controlled study to test whether taking daily supplements of a cocoa extract or a common multivitamin reduces the risk for developing heart disease, stroke, cancer, and other important health outcomes. Analyses of the data from COSMOS continue to yield insights about the connections between supplements and human health.
Reference: “Effect of cocoa extract supplementation on cognitive function: results from the clinic subcohort of the COSMOS trial” by Chirag M. Vyas, JoAnn E. Manson, Howard D. Sesso, Pamela M. Rist, Alison Weinberg, Eunjung Kim, M Vinayaga Moorthy, Nancy R. Cook and Olivia I. Okereke, 7 December 2023, The American Journal of Clinical Nutrition.
DOI: 10.1016/j.ajcnut.2023.10.031
The study was led by Mass General Brigham researchers, Dr. Chirag Vyas and Dr. Olivia I. Okereke at Massachusetts General Hospital, and Dr. Howard Sesso and Dr. JoAnn Manson at Brigham and Women’s Hospital.
The COcoa Supplement and Multivitamin Outcomes Study (COSMOS) is supported by an investigator-initiated grant from