Hugo Lloris, Steven Mandanda, Raphael Varane and Karim Benzema all called it a day after Les Bleus’ defeat in the World Cup final and France are also missing several injured stars.
The injured Christopher Nkunku and Ousmane Dembele are absent from the attack with N’Golo Kante, Presnel Kimpembe, Wesley Fofana, Lucas Hernandez and William Saliba unavailable.
Deschamps could therefore end up handing debuts to Jean-Clair Todibo and Khephren Thuram of Nice while former Nottingham Forest goalkeeper Brice Samba is also competing for a first appearance for the national team.
Despite the upheaval, a strong France line-up is still very much available and the 4-2-3-1 seen at the World Cup is most likely to feature heavily again in Euro 2024 qualification.
Mbappe is set to start on the left with Olivier Giroud up front and Kingsley Coman on the opposite flank. Antoine Griezmann should start despite being snubbed as France’s new captain by his coach.
Netherlands boss Ronald Koeman will pick the first squad of his second tenure in charge of the the Oranje.
In leaving out Bayer Leverkusen right-back Jeremie Frimpong, the boss indicated a move to a back four as he cited the ex-Celtic player’s inexperience in such a system when making his decision.
Frenkie de Jong is a key absentee through injury and Steven Bergwijn also misses out. Denzel Dumfries is suspended which could mean a debut for Lutsharel Geertruida while Daley Blind could win his 100th cap in Paris.
World Cup goalkeeper Andries Noppert misses out through injury, leading to a tussle between Jasper Cillessen, Mark Flekken of Freiburg and uncapped Anderlecht youngster Bart Verbruggen for the gloves.
Predicted France XI: Maignan; Kounde, Konate, Upamecano, Hernandez; Tchouameni, Rabiot; Coman, Griezmann, Mbappe; Giroud.
Predicted Netherlands XI: Cillessen; Geertruida, De Ligt, Van Dijk, Ake; Berguhis, De Roon, Wijnaldum; Malen, Gakpo, Depay.