A new study examined how artepillin C impacts both healthy and cancerous cells, alongside investigating how changes in the pH of the medium influence its effectiveness.
Propolis has long been used in traditional medicine and has won attention from the scientific community following proof of its health benefits, which include antioxidant, anti-inflammatory, antimicrobial, antitumor, and immunomodulatory properties.
Its composition varies according to origin, geographic location, and the bee 16/09633-4, 17/23426-4, 18/22214-6 and 20/12129-1). According to Pazin, it contributes to a deeper understanding of the substance’s action mechanisms and provides insights for future research leading to innovative treatments for cancer.
“However, although in vitro trials have demonstrated high efficiency for this molecule’s biological activities, oral or topical administration to patients would be hindered by certain particularities, such as low absorption and bioavailability,” Pazin said. “In this context, strategies to enhance its therapeutic action will be required in order for progress to be possible in the use of artepillin C against tumors. An example would be the deployment of nanocarriers for controlled release.”
Reference: “pH-Dependence Cytotoxicity Evaluation of Artepillin C against Tumor Cells” by Wallance M. Pazin, Renata R. Miranda, Karina A. Toledo, Frank Kjeldsen, Carlos J. L. Constantino and Jonathan R. Brewer, 8 November 2023, Life.
DOI: 10.3390/life13112186