Researchers have identified PDE4B as a potential new target for treating Alzheimer’s disease. By reducing PDE4B activity in a mouse model, they observed significant improvements in memory and brain glucose metabolism, providing hope for new therapeutic strategies for Alzheimer’s and possibly other dementias. Further research on PDE4B inhibiting drugs is needed to explore their efficacy in Alzheimer’s treatment.
Scientists at the University of Leeds and Lancaster University in the UK have discovered a potential new target for DOI: 10.1038/s41386-024-01852-z
The research was supported by the Dunhill Medical Trust, BBSRC, Alzheimer’s Research UK, and the Scientific and Technological Research Council of Turkey.