Researchers at Osaka University uncover the mechanism by which cysteine activates a crucial regulator of cell growth in yeast.
Amino acids serve as life’s fundamental components. They are sourced from our diet, and our bodies utilize them to create proteins. These proteins are crucial for growth, development, and various other processes. Yet, prior to utilizing these building blocks, the body must first detect their presence.
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The Role of Amino Acids in TORC1 Activation
What’s more, cysteine is not the only amino acid that triggers TORC1. All 20 amino acids were found to differently affect TORC1 using two ‘pathways’: Pib2 and Gtr. A pathway can be thought of as a specific chain reaction that leads to certain outcomes in a cell. The team set out to elucidate how each amino acid uses these pathways to affect TORC1.
“Some amino acids primarily use the Pib2 pathway, while others primarily use Gtr,” explains senior author Takeshi Noda. “We also identified amino acids that can use either pathway and some that need both. This work excites us because it deepens our understanding of how amino acids control cell growth and autophagy, and how each amino acid is detected.”
In humans, faulty TORC1 function has been linked to diseases like cancer, diabetes, and dementia. A fuller understanding of how TORC1 is switched on and off, and how each amino acid is detected, could help researchers find new treatments for these diseases – an exciting prospect indeed.
Reference: “Pib2 is a cysteine sensor involved in TORC1 activation in Saccharomyces cerevisiae” by Qingzhong Zeng, Yasuhiro Araki and Takeshi Noda, 20 December 2023, Cell Reports.
DOI: 10.1016/j.celrep.2023.113599