Many cancer types are caused by gene fusions that bring together parts of two different genes, often changing the activity of one of the partners. Although fusion transcripts result from structural variants on the DNA level such as translocations, inversions, or deletions, not all DNA fusions form relevant fusion genes at the RNA and protein levels. RNA-level analysis with panel enrichment provides scientists with better determination of the biological consequence of fusions and high sensitivity for fixed and paraffin embedded clinical specimens that contain degraded material with potentially low tumor content.
Download this application note from Twist Biosciences and CeGaT to learn about fusion detection panels that cover relevant targets for therapeutic development, tumor diagnostics, and beyond.