Scientists at Oak Ridge National Laboratory are advancing cancer treatment research by designing drugs that target the metabolic pathways cancer cells rely on for growth. By mapping the structure of a key enzyme with neutrons and X-rays, they aim to develop treatments for aggressive cancers, including lung and breast cancer.
After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for DOI: 10.1038/s42004-023-00964-9
In addition to Kovalevsky and Drago, the study’s coauthors include Claudia Campos, Mattea Hooper, Aliyah Collins, Oksana Gerlits, Kevin L. Weiss, Matthew P. Blakeley and Robert S. Phillips. Complementary neutron and x-ray measurements were performed at the Institut Laue-Langevin, France, and the Advanced Photon Source, or APS, at Argonne National Laboratory.
HFIR, SNS, and APS are DOE Office of Science user facilities.